Nicole McPherson's team at Adelaide did not send anything to space. They loaded human, mouse and pig sperm into a microchannel slide, plugged both ends, and set it inside a box that rotates on two independent axes according to a random walk algorithm. The box lives in an ordinary laboratory incubator at 37 degrees. It brings the sample below 0.1g within two minutes.
Which is to say it does not remove gravity. Gravity is still there, pulling on everything in the room, including the box. What the box does is change gravity's direction faster than a cell can average it out. The cell is not weightless. The cell is confused.
Everything written this week about human reproduction beyond Earth rests on the proposition that those two states are close enough.
The best section of this paper is the one establishing that the box is not simply stirring the sample. A rotating vessel mixes fluid. If it mixes fluid, then sperm arriving at the far end of a channel have not necessarily swum there, and the entire experiment collapses into a very expensive demonstration of convection.
So the team ran the controls. They tested how sample position relative to the rotational axis affected motility and found that outer channels degraded it, probably through fluid shear, so they used only the center wells for everything afterward. They put phenol stained media and fluorescent beads in the channel openings to confirm that nothing was being carried across passively. They washed the seminal plasma out of every human sample because viscosity differences were causing mixing. They ran rotational controls, spinning the samples without nullifying gravity, to separate the effect of the machine from the effect of the simulated condition.
The rotational control caught something. Curvilinear velocity dropped 20 percent in the rotational control (P = 0.04), a decline that did not appear in the simulated microgravity condition. The control performed worse than the treatment on one measure. They reported it anyway.
None of this made the coverage. It is the reason to believe the coverage.
Human sperm under simulated microgravity were significantly less likely to traverse the channel and reach the collection point, in standard media (P = 0.002) and in media formulated to mimic female reproductive tract fluid (P = 0.007). Total motility, progressive motility, curvilinear velocity and lateral head displacement were all unchanged. The sperm were swimming exactly as well. They were arriving less often. That distinction is the whole finding, and it points at orientation rather than propulsion.
In mice, four hours of co-incubation under simulated microgravity cut fertilization by about 30 percent as measured by two cell development (P = 0.03). Extend the window to 24 hours and fertilization rates recover to baseline, but the embryos pay for it later, with delayed cleavage and reduced blastocyst cell numbers (P = 0.04 for epiblast count). In pigs, both fertilization (P = 0.01) and expanded blastocyst formation (P = 0.005) fell.
Then the interesting part. Sperm that did complete the channel under simulated microgravity bound hyaluronan better than controls (P = 0.04). Hyaluronan binding correlates with lower DNA fragmentation and better ICSI outcomes. The embryos they produced had more epiblast cells. Making the journey harder did not just reduce the number of arrivals. It changed who arrived.
Significant reductions in swim through recovery, given as P values (0.002 and 0.007). No percentage range for navigation appears anywhere in the results.
What ranThat the number finishing the maze dropped by 30 to 50 percent. The 30 percent figure in the paper describes a mouse fertilization rate, not a human navigation rate. The 50 percent has no anchor I can find. Probably interview phrasing, reported as if read off a table.
Progesterone at 10 micromolar did not restore navigation. At 100 micromolar it did, fully. The authors note that progesterone's actual chemoattractant activity operates at picomolar concentrations, and attribute the gap to poor diffusion across the microchannel within the experimental window.
What ranThat adding progesterone improved navigation, with no dose given. The rescue required roughly eight orders of magnitude above physiology. That is a fact about the apparatus at least as much as a fact about the sperm, and it is the load bearing caveat under every sentence suggesting chemical cues might solve this.
China's Shijian 10 launched on 6 April 2016 carrying more than 6,000 mouse embryos at the two and four cell stages. The Ronca and Alberts pregnancy work flew Norway rats on nine and eleven day space shuttle missions, each landing on gestational day 20.
What ranThat SJ-10 launched in 2020 (that is the year the National Science Review paper appeared), that its embryos developed from a single cell (no zygotes flew), and that the rats went to the International Space Station in the early 2000s. The station had no crew until November 2000. In each case the publication year was mistaken for the flight year, and the most famous orbital laboratory was substituted for the actual vehicle.
Buried in the methods, after the description of the random walk algorithm, is this: the gravity bias system is proprietary to Firefly Biotech, and the authors acknowledge that reliance on a proprietary device may present a limitation in reproducibility.
That is an unusually clean admission. The instrument that defines the independent variable is a commercial black box. Another lab can buy the same box, but cannot inspect what it does, and cannot build one. The paper's central claim is that a machine successfully impersonated space, and the machine's impersonation technique is a trade secret.
They published the control algorithms anyway, deposited to Zenodo, which is more than the situation required of them.
There is also the matter of what the box cannot contain. There is no radiation in an incubator in Adelaide. The paper is explicit about this being the point, since real spaceflight cannot separate microgravity from cosmic rays, and the clinostat can. The coverage then places these results a few paragraphs upstream of a section on galactic cosmic rays damaging embryonic DNA, and lets the reader do the stitching. Two different experiments, two different variables, one continuous narrative.
The honest version of this study is that we do not know what happens to human reproduction in space, and this is our best available way of not knowing it. That is worth more than it sounds. A good simulator tells you which questions survive the simulation.
The finding most likely to matter never leaves Earth. Fewer sperm completed the channel, and the ones that did bound hyaluronan better and built embryos with more epiblast. Microgravity worked as a selection filter. Somebody should point that at an IVF lab and stop talking about Mars.
Sources
Primary paper: Lyons HE, Nikitaras V, Arman BM, et al. Simulated microgravity alters sperm navigation, fertilization and embryo development in mammals. Communications Biology 2026;9:401. Open access. nature.com
The coverage: Bolakhe S. Can Humans Get Pregnant in Space? National Geographic, 26 August 2026. nationalgeographic.com
SJ-10 embryos: Lei X, et al. Development of mouse preimplantation embryos in space. National Science Review 2020;7:1437-1446. academic.oup.com
SJ-10 launch record: Shi Jian-10 mission profile, eoPortal. eoportal.org
Rat pregnancy in flight: Ronca AE, Alberts JR. Effects of spaceflight during pregnancy on labor and birth at 1 G. Journal of Applied Physiology 2000;89:849-854. PubMed 10926673
Chemoattractant baseline: Teves ME, et al. Progesterone at the picomolar range is a chemoattractant for mammalian spermatozoa. Fertility and Sterility 2006;86:745-749.